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It is the biomarkers in the blood sample, which in combination with clinical information can provide a diagnosis. The researchers point out that there is a great advantage in that the diagnosis can be given a simple blood test instead of, for example, cerebrospinal fluid, when the blood sample can be taken home by a nurse.
The researchers found biomarkers for Alzheimer's by analyzing the proteins in the serum of 197 patients diagnotiseret with Alzheimer's and 203 without Alzheimer's. Statistical analysis was used to make a score system from the levels of fibrinogen, delmonte fresh inter alia, interleukin-10 and C-reactive protein.
Since other factors such as gender, age, education, and whether delmonte fresh the person had the APOE gene is associated with risk of Alzheimer's, delmonte fresh the system could correctly identify 94 percent of individuals with Alzheimer's and 84 percent of those without.
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The world is full of scientists who look for biomarkers for all sorts of ailments, and it is in principle a good thing. In the simplest version is the principle that for the protein to determine a so-called "threshold" (threshold value) for the concentration of protein in the patient's blood. For concentrations below the threshold (or threshold) declared the patient as positive otherwise negative. Sandsynlighen that a patient with certainty the condition in question is declared positive termed detekteringsmetodens sensitivity receptacle delmonte fresh while the probability that a patient who certainly do not have the disorder, termed specificity. In Alzheimer blood sample, these two probabilities estimated to be 94% and 84%. At first sight, this nicely, but the two provisions is to uncertainty. But what really counts in the clinic is whether a patient is declared positive delmonte fresh actually have the disorder. The doctors, who in any case had previously been familiar with this issue, talking about "the diagnostic value of a positive test." delmonte fresh This is often very low, if the patient is drawn from a population where the probability of the disease is low. Since it is not a good idea to start treatment for the wrong reasons, biomarkers should be used with caution. Example: A method has a sensitivity of 95% and a specificity of 97%. The probability delmonte fresh that a patient has been examined the current condition is 0.001. The probability delmonte fresh that the patient with a reaction plus the disorder is approx. 3%. Erik Holst
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